Classical and modern techniques for natural product extraction and isolation

Purifying bioactive compounds from complex biological matrices demands reliable methods spanning established and emerging approaches. Natural Products Extraction and Isolation presents strategies and techniques for extracting and isolating compounds from plants, microorganisms, and marine organisms. Written by two recognized natural products chemists, the book connects laboratory research with applications in pharmacology, drug discovery, and related disciplines.

Coverage extends from classical chromatographic separation methods to advanced techniques including supercritical fluid extraction and applications of artificial intelligence in natural products research. The book addresses bioactive compounds from diverse biological sources, encompassing microbial and marine products alongside multiple classes of phytochemicals, providing sufficient practical detail to support direct implementation in the laboratory.

Readers will also find:

• Hands-on protocols for isolating specific compound classes from plant, microbial, and marine source materials in research settings
• Guidance on selecting extraction strategies based on target compound properties, source organism type, and downstream analytical requirements
• Discussion of how artificial intelligence tools can streamline compound identification and optimize extraction workflows in discovery programs
• Detailed treatment of supercritical fluid extraction parameters, advantages, and practical considerations for natural products laboratories
• Coverage linking isolation techniques to characterization of bioactive substances and their properties for pharmaceutical development applications

Natural Products Extraction and Isolation serves natural product chemists, organic and medicinal chemists, pharmaceutical chemists, pharmacologists, and pharmacognosists seeking an authoritative single-volume resource. Both experienced researchers and those entering the field will find practical, implementable methods grounded in current best practice.

Satyajit D. Sarker, PhD, is Professor of Pharmacy and Director of the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores University. He is the Founding Head of the Centre for Natural Products Discovery and Founding Chair of the Society for Natural Products Discovery, a registered charity in the UK.

Lutfun Nahar, PhD, is a Medicinal and Natural Products Chemist at the School of Biomedical Sciences, University of Ulster at Coleraine. A Fellow of the Higher Education Academy with over 550 publications, she holds a degree in Chemistry from Exeter University and earned her PhD in Synthetic Medicinal Chemistry from Aberdeen University.