{"product_id":"9781394326228","title":"Peptidomimetics in Drug Discovery","description":"\u003ch1\u003ePeptidomimetics in Drug Discovery\u003c\/h1\u003e \u003ch2\u003eTrabocchi, Andrea\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFrom synthetic methods to peptide-based drugs in three integrated sections\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003ePeptides offer high potency and target specificity, yet low metabolic stability limits their direct therapeutic use. \u003ci\u003ePeptidomimetics in Drug Discovery\u003c\/i\u003e presents an integrated approach to overcoming these limitations through synthetic methodology, scaffold design, and medicinal chemistry applications. Organized in three logical sections, the book progresses from foundational concepts and chemistry toolbox development through scaffold construction to successful case studies of approved peptide-based drugs. \u003c\/p\u003e\u003cp\u003eDetailed coverage spans unnatural amino acid chemistry, amino acid-side chain isosteres, backbone and dipeptide isosteres, cyclic scaffolds, foldamers, macrocyclic peptidomimetics and stapled peptides. Hit-to-lead case studies feature the development of nirmatrelvir, the peptidomimetic SARS-CoV-2 antiviral, alongside therapeutic applications in CNS disorders and cancer. \u003c\/p\u003e\u003cp\u003eThe book also covers: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eBioisosterism principles applied to peptide bond replacement and their role in optimizing pharmacokinetic properties of lead compounds\u003c\/li\u003e \u003cli\u003eScaffolds for combinatorial chemistry of peptidomimetics enabling systematic exploration of chemical space around peptide-derived structures\u003c\/li\u003e \u003cli\u003eConcepts linking computational chemistry and biophysics to rational peptidomimetic design for target-specific drug candidates\u003c\/li\u003e \u003cli\u003ePractical approaches to improving molecular stability and bioavailability while retaining the biological activity of parent peptide sequences\u003c\/li\u003e \u003cli\u003eStrategies connecting early-stage hit identification with lead optimization through structure-activity relationships in peptidomimetic drug development\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePeptidomimetics in Drug Discovery\u003c\/i\u003e serves researchers in academia and industry working across medicinal chemistry, pharmaceutical research, and peptide-based drug development. It is equally relevant to postgraduates and investigators in computational chemistry, biophysics, and biomedical research seeking to advance peptide-derived lead compounds toward therapeutic application.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Wiley\u003c\/p\u003e \u003cp\u003ePublication Date: 2027-01-07\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781394326228\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: cm xcm\u003c\/p\u003e \u003cp\u003ePages: 384\u003c\/p\u003e ","brand":"Wiley","offers":[{"title":"Default Title","offer_id":50085700370572,"sku":"9781394326228","price":168.3,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781394326228.jpg?v=1779496161","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781394326228","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}