{"product_id":"9781119953234","title":"Metals in Cells","description":"\u003ch3\u003eEIC Books\u003c\/h3\u003e\u003ch1\u003eMetals in Cells\u003c\/h1\u003e\u003ch3\u003eValeria Culotta | Robert A. Scott\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eOver the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.\u003c\/p\u003e \u003cp\u003eThis new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include:  regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to \"foreign\" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.\u003c\/p\u003e \u003cp\u003eThe content from this book will publish online, as part of \u003ci\u003eEIBC\u003c\/i\u003e in December 2013, find out more about the \u003ci\u003eEncyclopedia of Inorganic and Bioinorganic Chemistry\u003c\/i\u003e, the essential online resource for researchers and students working in all areas of \u003ca href=\"http:\/\/onlinelibrary.wiley.com\/book\/10.1002\/9781119951438\"\u003einorganic and bioinorganic chemistry\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eProf. Robert A. Scott\u003c\/b\u003e (Editor-in-Chief \u003ci\u003eEncyclopedia of Inorganic and Bioinorganic Chemistry\u003c\/i\u003e)\u003cbr\u003eDistinguished Research Professor, University of Georgia, USA.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProf. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences\u003c\/b\u003e\u003cbr\u003eResearch in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, \u003ci\u003eC. elegans\u003c\/i\u003e and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e14 October 2013\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119953234\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e608\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e67.04\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379965489292,"sku":"9781119953234","price":210.56,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119953234.jpg?v=1780239051","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119953234","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}