{"product_id":"9781119950608","title":"Peptidomimetics in Organic and Medicinal Chemistry The Art of Transforming Peptides in Drugs","description":"\u003ch1\u003ePeptidomimetics in Organic and Medicinal Chemistry\u003c\/h1\u003e\u003ch2\u003eThe Art of Transforming Peptides in Drugs\u003c\/h2\u003e\u003ch3\u003eAntonio Guarna | Andrea Trabocchi\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Physical \u0026amp; Theoretical\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eA peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeptidomimetics in Organic and Medicinal Chemistry\u003c\/i\u003e outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003eAndrea Trabocchi\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDepartment of Chemistry “Ugo Schiff”, University of Florence, Italy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntonio Guarna\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDepartment of Chemistry “Ugo Schiff”, University of Florence, Italy\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e14 April 2014\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119950608\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e320\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e22.72\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44315497201804,"sku":"9781119950608","price":161.06,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119950608.jpg?v=1780237575","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119950608","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}