{"product_id":"9781119799979","title":"A Guide to Sample Size for Animal-based Studies","description":"\u003ch1\u003eA Guide to Sample Size for Animal-based Studies\u003c\/h1\u003e\u003ch3\u003ePenny S. Reynolds\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Biostatistics\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003eA Guide to Sample Size for Animal-based Studies\u003c\/b\u003e \u003cp\u003e\u003cb\u003eUnderstand a foundational area of experimental design with this innovative reference\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eAnimal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.  \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. \u003c\/p\u003e\n\u003cp\u003eThis book offers: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStep-by-step guidance in diverse methods for approximating and refining sample size\u003c\/li\u003e \u003cli\u003eDetailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies\u003c\/li\u003e \u003cli\u003eSample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies\u003c\/li\u003e \u003cli\u003eNumerous worked examples, using real data from published papers, together with SAS and R code\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003ePenny S. Reynolds, PhD,\u003c\/b\u003e is a Research Assistant Professor in the Department of Anesthesiology, College of Medicine, and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, USA. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e19 September 2023\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Blackwell\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119799979\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003ePaperback \/ softback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e288\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e25.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44384770752652,"sku":"9781119799979","price":70.16,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119799979_6c4d574f-2aea-440e-8391-5aa9c8ed1901.jpg?v=1780185456","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119799979","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}