{"product_id":"9781119774129","title":"Protein Homeostasis in Drug Discovery A Chemical Biology Perspective","description":"\u003ch1\u003eProtein Homeostasis in Drug Discovery\u003c\/h1\u003e\u003ch2\u003eA Chemical Biology Perspective\u003c\/h2\u003e\u003ch3\u003eMilka Kostic | Lyn H. Jones\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Organic\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003eProtein Homeostasis in Drug Discovery\u003c\/b\u003e \u003cp\u003e\u003cb\u003eComprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProtein Homeostasis in Drug Discovery\u003c\/i\u003e highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein’s activity may not be the only factor to consider when developing therapeutic agents.  \u003c\/p\u003e\n\u003cp\u003eThe chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality.  \u003c\/p\u003e\n\u003cp\u003eReaders interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, those interested in the link between biological function and regulating protein levels in living organisms, especially in the context of drug discovery, will learn from numerous examples discussed in this book. \u003c\/p\u003e\n\u003cp\u003eIn \u003ci\u003eProtein Homeostasis in Drug Discovery\u003c\/i\u003e, readers can expect to find information on: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProtein folding, quality control, pharmacology, and drug targeting processes\u003c\/li\u003e \u003cli\u003e Recent advances in our understanding of protein homeostasis, covering emerging technologies and opportunities for therapeutic intervention \u003c\/li\u003e \u003cli\u003e Targeted protein degradation (TPD) and strategies such as PROTACs and molecular glues, including a chapter on TPD as an antiviral drug discovery strategy\u003c\/li\u003e \u003cli\u003e Drug discovery and development efforts aimed at correcting, stabilizing, and rescuing proteins, with examples included\u003c\/li\u003e \u003cli\u003e Advantages and key shortcomings of both phenotypic and target-based traditional drug discovery methods\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eCollectively, \u003ci\u003eProtein Homeostasis in Drug Discovery\u003c\/i\u003e offers the reader an opportunity to learn more about the importance of considering and targeting protein homeostasis. The text is a must-read resource for academics, professionals in the pharmaceutical industry, and advanced students in various science-related fields.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003eMilka Kostic, PhD,\u003c\/b\u003e is the Program Director for Chemical Biology at the Dana-Farber Cancer Institute and her interests include advocating for the importance of chemical biology as a critical link in the chemistry-biology-medicine continuum. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLyn H. Jones, PhD,\u003c\/b\u003e is currently Director of the Center for Protein Degradation at the Dana-Farber Cancer Institute and his interests include using chemogenomics and chemoproteomics to advance new therapeutic modalities. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e08 December 2022\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119774129\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e560\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e35.52\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310475178124,"sku":"9781119774129","price":208.76,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119774129_e5cd2c70-ff4a-40cf-b984-5d04428cf96e.jpg?v=1780158043","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119774129","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}