{"product_id":"9781119238485","title":"Reversible Ligand Binding Theory and Experiment","description":"\u003ch1\u003eReversible Ligand Binding\u003c\/h1\u003e\u003ch2\u003eTheory and Experiment\u003c\/h2\u003e\u003ch3\u003eAndrea Bellelli | Jannette Carey\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003ePresents the physical background of ligand binding and instructs on how experiments should be designed and analyzed\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eReversible Ligand Binding: Theory and Experiment\u003c\/i\u003e discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s).\u003c\/p\u003e \u003cp\u003eTopics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBridges theory of ligand binding and allostery with experiments\u003c\/li\u003e \u003cli\u003eApplies historical and physical insight to provide a clear understanding of ligand binding\u003c\/li\u003e \u003cli\u003eWritten by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery\u003c\/li\u003e \u003cli\u003eBased on FEBS Advanced Course lectures on the topic\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eReversible Ligand Binding: Theory and Experiment\u003c\/i\u003e is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e   \u003cp\u003e\u003cb\u003eAndrea Bellelli, PhD\u003c\/b\u003e is a Professor of Biochemistry at the University of Rome Sapienza. He chaired the Department of Biochemical Sciences \"A. Rossi Fanelli\" and currently chairs the Medicine and Surgery \"B\" school at the same University. His research focuses on structural and functional properties of oxygen carrying proteins. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eJannette Carey, PhD\u003c\/b\u003e is a Professor of Chemistry at Princeton University and a visiting scientist of the Academy of Sciences of the Czech Republic at Nové Hrady, where she initiated and organizes a biennial FEBS practical and lecture course, Ligand binding theory and practice. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e17 January 2018\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119238485\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e304\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e22.4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44378626424972,"sku":"9781119238485","price":115.16,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119238485_37ec3cbb-4237-4607-8c16-1c24e64bb084.jpg?v=1780241217","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119238485","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}