{"product_id":"9781119099482","title":"Applied Biophysics for Drug Discovery","description":"\u003ch1\u003eApplied Biophysics for Drug Discovery\u003c\/h1\u003e\u003ch3\u003eDonald Huddler | Edward R. Zartler\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biophysics\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003ci\u003eApplied Biophysics for Drug Discovery\u003c\/i\u003e is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. \u003c\/p\u003e \u003cp\u003eThis text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR.\u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cp\u003e•          Design considerations in biophysical-based lead screening\u003c\/p\u003e \u003cp\u003e•          Thermodynamic characterization of protein-compound interactions\u003c\/p\u003e \u003cp\u003e•          Characterizing targets and screening reagents with HDX-MS\u003c\/p\u003e \u003cp\u003e•          Microscale thermophoresis methods (MST)\u003c\/p\u003e \u003cp\u003e•          Screening with Weak Affinity Chromatography\u003c\/p\u003e \u003cp\u003e•          Methods to assess compound residence time\u003c\/p\u003e \u003cp\u003e•          1D-NMR methods for hit identification\u003c\/p\u003e \u003cp\u003e•          Protein-based NMR methods for SAR development\u003c\/p\u003e \u003cp\u003e•          Industry case studies integrating multiple biophysical methods\u003c\/p\u003e \u003cp\u003eThis text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eDonald Huddler,\u003c\/b\u003e Widener University Delaware Law School, Wilmington, USA.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEdward R. Zartler\u003c\/b\u003e is Chief Scientific Officer at Quantum Tessera Consulting, LLC, USA. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e09 October 2017\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119099482\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e320\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e27.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44384830587020,"sku":"9781119099482","price":164.66,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119099482_0ffb32fd-676f-453a-b9bb-0e4da3eb2bf3.jpg?v=1780158971","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119099482","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}