{"product_id":"9781119074915","title":"Protein Carbonylation Principles, Analysis, and Biological Implications","description":"\u003ch3\u003eWiley Series on Mass Spectrometry\u003c\/h3\u003e\u003ch1\u003eProtein Carbonylation\u003c\/h1\u003e\u003ch2\u003ePrinciples, Analysis, and Biological Implications\u003c\/h2\u003e\u003ch3\u003eJoaquim Ros\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Spectroscopy \u0026amp; Spectrum Analysis\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eProtein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology.\u003c\/p\u003e \u003cp\u003eIn this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur.\u003c\/p\u003e \u003cp\u003eThe scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems\u003c\/li\u003e \u003cli\u003eMass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described\u003c\/li\u003e \u003cli\u003eAging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation\u003c\/li\u003e \u003cli\u003eDirect oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways\u003c\/li\u003e \u003cli\u003eEmerging methods for characterizing carbonylated protein networks and affected metabolic pathways\u003c\/li\u003e \u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv\u003e   \u003cp\u003e \u003cb\u003eJoaquim Ros\u003c\/b\u003e is Professor at the University of Lleida. From 1995 his research interest has been  focused on studying the effect of oxidative stress on proteins in several models (from bacteria to  humans) and how this damage affects protein function. He is the head of the Dept. of Basic Medical  Sciences, Faculty of Medicine, University of Lleida.   \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e26 June 2017\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119074915\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e416\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e24.8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44385463533708,"sku":"9781119074915","price":182.66,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119074915_6ae896c0-7913-496c-97e6-8febfd609ab2.jpg?v=1780173600","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781119074915","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}