Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks 

• Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis
• Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP
• Explains the most efficient ways of formulating a biological problem using mathematical optimization
• Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations
• Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems

Costas D. Maranas is a Donald B. Broughton Professor in the Department of Chemical Engineering at Pennsylvania State University, USA. Dr. Maranas is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). In 2002 he was awarded by AIChE the Allan P. Colburn Award for Excellence in Publications by a Young Member of the Institute.

Ali R. Zomorrodi obtained his PhD in Chemical Engineering at Pennsylvania State University and is currently a Postdoctoral Research Associate at Boston University, USA. Dr. Zomorrodi's areas of expertise include optimization-based modeling and model-driven analysis of biological networks.