{"product_id":"9781118898642","title":"ADME and Translational Pharmacokinetics \/ Pharmacodynamics of Therapeutic Proteins Applications in Drug Discovery and Development","description":"\u003ch1\u003eADME and Translational Pharmacokinetics \/ Pharmacodynamics of Therapeutic Proteins\u003c\/h1\u003e\u003ch2\u003eApplications in Drug Discovery and Development\u003c\/h2\u003e\u003ch3\u003eHonghui Zhou | Frank-Peter Theil\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eWith an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDetails cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic \/ pharmacodynamics) modeling for biologic drugs\u003c\/li\u003e \u003cli\u003eCombines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective\u003c\/li\u003e \u003cli\u003eIncludes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines\u003c\/li\u003e \u003cli\u003ePresents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan\u003c\/li\u003e \u003cli\u003eProvides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain\u003c\/li\u003e \u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cb\u003eHonghui Zhou\u003c\/b\u003e is a Senior Director and Janssen Fellow, at Janssen Research \u0026amp; Development, LLC and US head of Pharmacological and Translational Modeling. Board-certified by the American Board of Clinical Pharmacology and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and American College of Clinical Pharmacology (ACCP), he has authored 200 peer-reviewed scientific papers, book chapters, and conference abstracts and co-edited the book \u003ci\u003eDrug-Drug Interactions for Therapeutic Biologics\u003c\/i\u003e (Wiley, 2013).\u003cbr\u003e\u003cbr\u003e\u003cb\u003eFrank-Peter Theil\u003c\/b\u003e heads nonclinical development at UCB Biopharma. Dr. Theil has authored and co-authored 40 research publications, three book chapters and he has given numerous invited presentations at national and international scientific meetings. He is a member of the American Association of Pharmaceutical Scientists (AAPS) and American Society of Clinical Pharmacology and Therapeutics (ASCPT).\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e23 November 2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781118898642\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e480\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e47.68\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379090944140,"sku":"9781118898642","price":149.35,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781118898642.jpg?v=1780201092","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781118898642","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}