{"product_id":"9781118772324","title":"Matrix Metalloproteinase Biology","description":"\u003ch1\u003eMatrix Metalloproteinase Biology\u003c\/h1\u003e\u003ch3\u003eIrit Sagi | Jean Gaffney\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Developmental Biology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eDiscussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, \u003ci\u003eMatrix Metalloproteinase Biology\u003c\/i\u003eis a collection of chapters written by leaders in the field of MMPs.  The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases.\u003cbr\u003e \u003cbr\u003e The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics.\u003cb\u003e \u003c\/b\u003eThe following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on \u003ci\u003ein vivo\u003c\/i\u003e research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. \u003c\/p\u003e Written and edited by leaders in the field, \u003ci\u003eMatrix Metalloproteinase Biology\u003c\/i\u003e addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.\u003c\/div\u003e\u003cdiv\u003e \u003cb\u003eIrit Sagi\u003c\/b\u003e is Incumbent of the Maurizio Pontecorvo Professorial Chair in the Department of Biological Regulation at the Weizmann Institute of Science, Rehovot, Israel. \u003cbr\u003e\u003cbr\u003e\u003cb\u003eJean P. Gaffney\u003c\/b\u003e completed her postdoctoral work in Dr. Sagi’s laboratory at the Weizmann Institute of Science, Rehovot, Israel. She is an Assistant Professor of Chemistry at Baruch College, City University of New York, New York, NY, USA.\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e03 August 2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Blackwell\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781118772324\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e232\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e23.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379757379724,"sku":"9781118772324","price":155.66,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781118772324_6aae6125-c5c6-4a49-a833-cfeb4bbde745.jpg?v=1780176880","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781118772324","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}