{"product_id":"9781118159248","title":"Handbook of LC-MS Bioanalysis Best Practices, Experimental Protocols, and Regulations","description":"\u003ch1\u003eHandbook of LC-MS Bioanalysis\u003c\/h1\u003e\u003ch2\u003eBest Practices, Experimental Protocols, and Regulations\u003c\/h2\u003e\u003ch3\u003eWenkui Li | Jie Zhang | Francis L. S. Tse\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Spectroscopy \u0026amp; Spectrum Analysis\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eConsolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results.\u003c\/p\u003e \u003cp\u003ePresenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eHandbook of LC-MS Bioanalysis\u003c\/i\u003e features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eFundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring\u003c\/li\u003e \u003cli\u003eThe current understanding of regulations governing LC-MS bioanalysis\u003c\/li\u003e \u003cli\u003eBest practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest\u003c\/li\u003e \u003cli\u003eExperimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWith its focus on current bioanalytical practice, \u003ci\u003eHandbook of LC-MS Bioanalysis\u003c\/i\u003e enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003eWENKUI LI, PhD,\u003c\/b\u003e is Senior Fellow in the Department of Drug Metabolism \u0026amp; Pharmacokinetics at Novartis Institutes for BioMedical Research, where he focuses on regulated LC-MS\/MS bioanalysis for the toxicokinetic and pharmacokinetic assessment of drug candidates. Dr. Li is a member of the editorial board of \u003ci\u003eBiomedical Chromatography\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJIE ZHANG, PhD,\u003c\/b\u003e is Senior Fellow in the Department of Drug Metabolism \u0026amp; Pharmacokinetics at Novartis Institutes for BioMedical Research, where he focuses on regulated LC-MS bioanalysis for the toxicokinetic and pharmacokinetic assessment of drug candidates. In addition, Dr. Zhang evaluates and implements novel technologies and processes in regulated LC-MS bioanalysis.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFRANCIS L. S. TSE, PhD,\u003c\/b\u003e is Vice President of Drug Metabolism \u0026amp; Bioanalytics at Novartis Institutes for BioMedical Research, overseeing the unit's strategy and operations in North America and Asia. Dr. Tse is a Fellow of the American Association of Pharmaceutical Scientists, APhA Academy of Pharmaceutical Research and Science, and American College of Clinical Pharmacology.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e21 October 2013\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781118159248\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e704\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e67.52\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44378880245900,"sku":"9781118159248","price":159.26,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781118159248.jpg?v=1780183355","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781118159248","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}