{"product_id":"9781118007518","title":"Chemical Synthesis of Nucleoside Analogues","description":"\u003ch1\u003eChemical Synthesis of Nucleoside Analogues\u003c\/h1\u003e\u003ch3\u003ePedro Merino\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003ci\u003e\u003cb\u003eCompiles current tested and proven approaches to synthesize novel nucleoside analogues\u003c\/b\u003e\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFeaturing contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eChanges to the heterocyclic base\u003c\/li\u003e \u003cli\u003eModification of substituents at the sugar ring\u003c\/li\u003e \u003cli\u003eReplacement of the furanose ring by a different carbo- or heterocyclic ring\u003c\/li\u003e \u003cli\u003eIntroduction of conformational restrictions\u003c\/li\u003e \u003cli\u003eSynthesis of enantiomers\u003c\/li\u003e \u003cli\u003ePreparation of hydrolitically stable C-nucleosides\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.\u003c\/p\u003e \u003cp\u003eThroughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.\u003c\/p\u003e \u003cp\u003eSynthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With \u003ci\u003eChemical Synthesis of Nucleoside Analogues\u003c\/i\u003e as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003ePEDRO MERINO, PhD,\u003c\/b\u003e is the Director of the Department of Synthesis and Structure of Biomolecules of the Institute of Chemical Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr. Merino has authored more than 200 publications, including several reviews and book chapters. His research spans asymmetric synthesis, target-oriented synthesis, organometallic chemistry, and asymmetric metal-assisted and organic catalysis. Recently, he has been investigating the use of computational chemistry to better understand reaction mechanisms.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e25 March 2013\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781118007518\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e912\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e48.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379071774860,"sku":"9781118007518","price":200.66,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781118007518.jpg?v=1780197820","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781118007518","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}