{"product_id":"9780792398592","title":"Developments in Cardiovascular Medicine: Experimental Approaches and Therapeutic Implications","description":"\u003ch1\u003eDevelopments in Cardiovascular Medicine: Experimental Approaches and Therapeutic Implications\u003c\/h1\u003e \u003ch2\u003eMarch, Keith L.\u003c\/h2\u003e \u003cp\u003eThe goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled \"Artificial Self-Assembling Systems for Gene Transfer\", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1997-03-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792398592\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-6277-1\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 516\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46311861223564,"sku":"9780792398592","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792398592.jpg?v=1771513493","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792398592","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}