{"product_id":"9780792387800","title":"Falk Symposium","description":"\u003ch1\u003eFalk Symposium\u003c\/h1\u003e \u003ch2\u003eScheppach, W.; Scheurlen, M.\u003c\/h2\u003e \u003cp\u003eThis book is the proceedings of Falk Symposium 128, held in  Würzburg, Germany, on May 2-3, 2002, and dedicated to the  important issue of colonic carcinogenesis and its underlying genetic  and environmental factors. \u003cbr\u003e  Colorectal cancer is one of the leading causes of cancer-related death  in industrialized countries. It has been recognized to be the  consequence of a dynamic process leading from hyperproliferative  epithelium through different classes of adenomas to invasive  carcinoma. This adenoma-carcinoma sequence has been  characterized on a molecular basis. Modern molecular biology has also  helped to clarify the clustering of colorectal cancer within families,  a phenomenon that has been known to clinicians for a long time. Thus,  the pathogenesis of the two distinct familial colon cancer syndromes  FAP (familial adenomatous polyposis) and HNPCC (hereditary  non-polyposis colorectal cancer) is increasingly being understood.  Thereby, an identification of affected people has become possible  before the disease has manifested. \u003cbr\u003e  There is also convincing evidence that the pathogenesis of sporadic  colonic cancer is modulated by environmental, mainly nutritional,  factors. Carcinogens seem to be far less important than the components  of the `normal' human diet. It is likely that the interplay between  protective and noxious dietary compounds determines the progression of  the adenoma-carcinoma sequence. Additionally, a broad spectrum  of drugs has been shown to affect colonic tumorigenesis, which  provides the rationale for chemoprevention strategies. These issues  set the scene for discussions on how genetic and environmental factors  may interact in the pathogenesis of colonic cancer, contributing fresh  ideas to the prevention of this most prevalent malignancy in the  industrialized world.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2003-01-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792387800\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 328\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541625991308,"sku":"9780792387800","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792387800.jpg?v=1770783647","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792387800","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}