{"product_id":"9780792383833","title":"Developments in Oncology","description":"\u003ch1\u003eDevelopments in Oncology\u003c\/h1\u003e \u003ch2\u003eGarte, Seymour\u003c\/h2\u003e \u003cp\u003eDespite recent progress in many areas of treatment and control,  cancer remains a frightening threat to everyone. While scientists have  known for decades that the majority of human cancers are caused by  environmental agents such as radiation and the chemicals in cigarette  smoke, not everyone who smokes gets lung cancer. Furthermore, many  people who assiduously avoid all possible risk from smoking, diet, and  pollution still succumb to some form of cancer later in life. Does  this mean that there is an element of blind chance in the underlying  mechanisms of human carcinogenesis? To what extent do genetic  influences play a role in determining the cancer risk of individuals?  \u003cbr\u003e  A number of `cancer families', in which several closely related  individuals have suffered from various specific forms of cancer, have  been studied by genetic epidemiologists. However, for the majority of  cancer cases, little or no discernible genetic influence or family  history is found. Recent research has discovered that for many of  these `sporadic' (non-familial) cancer cases, defects or aberrations  in certain metabolic genes not previously associated with genetic  cancer risk may contribute to either causing the disease or at least  increasing the chances of developing cancer. It is therefore possible  that much of what has previously passed for `bad luck' may turn out to  be a new type of `bad genes'. \u003cbr\u003e  \u003cem\u003eGenetic Susceptibility to Cancer\u003c\/em\u003e explains that this new idea of  `bad genes' may contain an unexpected positive side. The carcinogenic  effects of these metabolic genes, unlike those of the oncogenes and  tumor suppressor genes that are responsible for the inherited cancer  syndromes, can potentially be overcome or nullified. \u003cbr\u003e  \u003cem\u003eGenetic Susceptibility to Cancer\u003c\/em\u003e will provide a valuable  reference for health professionals, researchers, clinicians and  biomedical scientists who are interested in the current thinking in  this critically important areaof cancer management.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1998-11-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792383833\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4989-5\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 137\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46312030797964,"sku":"9780792383833","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792383833.jpg?v=1771516142","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792383833","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}