{"product_id":"9780792377900","title":"Endocrine Updates: Pathogenesis and Treatment","description":"\u003ch1\u003eEndocrine Updates: Pathogenesis and Treatment\u003c\/h1\u003e \u003ch2\u003eRapoport, Basil; McLachlan, Sandra M.\u003c\/h2\u003e \u003cp\u003eFrom the perspective of the investigator, Graves' disease is a  fascinating disorder with unique features and opportunities for study.  The discovery in 1956 that Graves' disease was caused by a humoral  factor, later shown to be an antibody to the TSH receptor, was a  triumph for modern investigative medicine. Rapid progress is now being  made in (i) understanding the molecular interaction between  autoantibodies and the TSH receptor, (ii) identifying the genes that  contribute to the predisposition to disease, (iii) developing an  animal model of Graves' disease, and (iv) identifying the long-sought  orbital antigen in ophthalmopathy. From the clinical standpoint,  although Graves' disease is eminently treatable, there is no  definitive cure. None of the therapeutic options are ideal. It is  hoped that rapid progress in understanding the pathogenesis of the  disease will lead to the ultimate goal of some form of immunotherapy  that will make antithyroid drugs, radioiodine and thyroidectomy  obsolete. \u003cbr\u003e  The chapters in \u003cem\u003eGraves' Disease: Pathogenesis and Treatment\u003c\/em\u003e  represent the viewpoints of many prominent clinicians and  investigators working in the field. The editors are grateful for their  contributions which cover an unusually comprehensive compendium of  subjects relating to the disease.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-06-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792377900\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4407-4\u003c\/p\u003e \u003cp\u003eDimensions: 244cm x170cm\u003c\/p\u003e \u003cp\u003ePages: 307\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46265576292492,"sku":"9780792377900","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792377900.jpg?v=1770785202","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792377900","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}