{"product_id":"9780792371571","title":"Excitation-Contraction Coupling and Cardiac Contractile Force","description":"\u003ch1\u003eExcitation-Contraction Coupling and Cardiac Contractile Force\u003c\/h1\u003e \u003ch2\u003eBers, Donald\u003c\/h2\u003e \u003cp\u003eHow is the heartbeat generated? What controls the strength of  contraction of heart muscle? What are the links between cardiac  structure and function? How does our understanding of skeletal and  smooth muscle and non-muscle cells influence our thinking about force  development in the heart? Are there important species differences in  how contraction is regulated in the heart? How do the new molecular  data fit together in understanding the heart beat? What goes wrong in  ischemia, hypertrophy, and heart failure? This book paints a modern  `portrait' of how the heart works and in this picture the author shows  a close-up of the structural, biochemical, and physiological links  between excitation and contraction. \u003cbr\u003e  The author takes the reader through a series of important,  interrelated topics with great clarity and continuity and also  includes many useful illustrations and tables. The book starts by  considering the cellular structures involved in  excitation-contraction coupling and then described the  characteristics of the myofilaments as the end effector of  excitation-contraction coupling. A general scheme of calcium  regulation is described and the possible sources and sinks of calcium  are discussed in simple, but quantitative terms. The cardiac action  potential and its many underlying currents are reviewed. Then the  characteristics of some key calcium transport systems (calcium  channels, sodium\/calcium exchange and SR calcium uptake and release)  are discussed in detail. This is then built into a more integrated  picture of calcium regulation in succeeding chapters by detailed  discussions of excitation-calcium coupling mechanisms (in  skeletal, cardiac, and smooth muscle), the interplay between calcium  regulatory processes, and finally mechanisms of cardiac inotropy,  calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and  heart failure). \u003cbr\u003e  \u003cem\u003eExcitation-Contraction Coupling and Cardiac Contractile  Force\u003c\/em\u003e \u003cem\u003e\u0026amp;endash; Second Edition\u003c\/em\u003e is an invaluable source of  information for anyone who is interested in how the heart beat is  controlled and especially suited for students of the cardiovascular  system at all levels from medical\/graduate students through senior  investigators in related fields.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2001-08-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003e ISBN-10: 9780792371571\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792371571\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-010-0658-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 427\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44343414915212,"sku":"9780792371571","price":198.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792371571_efeaff01-a8eb-4ebf-b9f2-048e889394cf.jpg?v=1755054717","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792371571","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}