{"product_id":"9780792366331","title":"Virtual Screening: An Alternative or Complement to High Throughput Screening?: Proceedings of the Workshop ‘New Approaches in Drug Design and Discovery’, special topic ‘Virtual Screening’, Schloß Rauischholzhausen, Germany, March 15–18, 1999","description":"\u003ch1\u003eVirtual Screening: An Alternative or Complement to High Throughput Screening?: Proceedings of the Workshop ‘New Approaches in Drug Design and Discovery’, special topic ‘Virtual Screening’, Schloß Rauischholzhausen, Germany, March 15–18, 1999\u003c\/h1\u003e \u003ch2\u003eKlebe, Gerhard\u003c\/h2\u003e \u003cp\u003eIn the next couple of years the human genome will be fully  sequenced. This will provide us with the sequence and overall function  of all human genes as well as the complete genome for many  micro-organisms. Subsequently it is hoped, by means of powerful  bioinformatic tools, to determine the gene variants that contribute to  various multifactorial diseases and genes that exist in certain  infectious agents but not humans. As a consequence, this will allow us  to define the most appropriate levels for drug intervention. It can be  expected that the number of potential drug targets will increase,  possibly by a factor of 10 or more. Nevertheless, sequencing the human  genome or, for that matter, the genome of other species will only be  the starting point for the understanding of their biological function.  Structural genomics is a likely follow-up, combined with new  techniques to validate the therapeutic relevance of such newly  discovered targets. Accordingly, it can be expected that in the near  future we will witness a substantial increase in novel putative  targets for drugs. To address these new targets effectively, we  require new approaches and innovative tools. At present, two  alternative, yet complementary, techniques are employed: experimental  high-throughput screening (HTS) of large compound libraries,  increasingly provided by combinatorial chemistry, and computational  methods for virtual screening and \u003cem\u003ede novo\u003c\/em\u003e design. \u003cbr\u003e  As kind of status report on the maturity of virtual screening as a  technique in drug design, the first workshop on new approaches in drug  design and discovery was held in March 1999, at Schloß  Rauischholzhausen, near Marburg in Germany. More than 80 scientists  gathered and discussed their experience with the different techniques.  The speakers were invited to summarize their contributions together  with their impressions on the present applicability of their approach.  Several of the speakers followed this requestwhich is summarized in  this publication.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-11-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792366331\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/0-306-46883-2\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 295\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541702111372,"sku":"9780792366331","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792366331.jpg?v=1770815004","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792366331","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}