{"product_id":"9780792364214","title":"Calcium: The molecular basis of calcium action in biology and medicine","description":"\u003ch1\u003eCalcium: The molecular basis of calcium action in biology and medicine\u003c\/h1\u003e \u003ch2\u003ePochet, R.; Donato, Rosario; Haiech, J.; Heizmann, Claus W.; Gerke, Volker\u003c\/h2\u003e \u003cp\u003eThe enormous and varied role of calcium in living systems is  now widely appreciated by both cell biologists and clinicians. The  identification and characterisation of new calcium binding proteins  and regulatory pathways is matched by the recognition of the  involvement of calcium binding proteins in a growing number of disease  states. This book is intended to introduce clinicians to fundamental  biological research, whilst at the same time attracting researchers to  the clinical world. \u003cbr\u003e  The publication of the book coincides with the elucidation of the  complete Human Genomic Sequence. As a result of this, scientists now  have access to an unprecedented array of data, from which new calcium  binding proteins and hence new regulatory pathways will undoubtedly be  discovered. It is a further aim of this book to provide a `key' to  open the door to the new postgenomic era. \u003cbr\u003e  The book is in three parts. The first section introduces the reader to  the role of calcium in cell biology, providing an appreciation of how  this small, simple, non-metabolisable agent can move rapidly and  silently through the different cellular compartments, thereby  influencing and controlling the fate of the cell. This section also  illustrates and dissects the often-complex interplay between calcium  and numerous agents in muscle and endocrine cells, neurons,  hepatocytes, and platelets. \u003cbr\u003e  In the second section the reader will discover the role of calcium and  its partners in common diseases such as migraine and drug dependence.  New classes of diseases such as annexinopathies, channelopathies,  calcium-sensing disorders, and citrullinemia are discussed, and the  authors give many new insights into the molecular mechanisms of the  diseases, thereby explaining how and why they occur. Such information  is clearly of primary importance for the pharmaceutical industry. New  ideas and concepts of neurodegenerative diseases are introduced, which  should stimulate new approaches.Clinicians will also have access, in  a comprehensive and authoritative yet highly readable chapter, to data  from recent large-scale clinical studies on the numerous and widely  prescribed calcium antagonists. \u003cbr\u003e  The final section gives information on new methods and devices for  calcium imaging, and illustrates how calcium movement and change can  be monitored and ingeniously utilised as a fast, cheap, and accurate  drug screening instrument.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-11-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792364214\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-010-0688-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 732\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541697196172,"sku":"9780792364214","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792364214.jpg?v=1770789238","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792364214","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}