{"product_id":"9780792359234","title":"Reproductive Immunology","description":"\u003ch1\u003eReproductive Immunology\u003c\/h1\u003e \u003ch2\u003eGupta, Satish Kumar\u003c\/h2\u003e \u003cp\u003e\u003cem\u003eReproductive Immunology\u003c\/em\u003e is a compilation of research  articles presented during the VII International Congress of  Reproductive Immunology which was held in New Delhi, India on 27-30  October 1998. The articles pertain to the following six major themes:  \u003c\/p\u003e\u003col\u003e \u003cli\u003eMolecular and Immunological Aspects of  Sperm-Egg Interaction \u003c\/li\u003e  \u003cli\u003eEmbryonic-Endometrial  Cross-Talk \u003c\/li\u003e  \u003cli\u003eImmunobiology of Pregnancy \u003c\/li\u003e  \u003cli\u003eAutoantibodies and  Infertility \u003c\/li\u003e  \u003cli\u003eImmunocontraception \u003c\/li\u003e  \u003cli\u003eMucosal Immunology and  Reproductive Tract Infections\u003c\/li\u003e  \u003c\/ol\u003e  . \u003cbr\u003e  The first section deals with our current understanding of various  steps involved in fertilization. The functional significance of sperm  surface mannosidase and glutathione S-transferases to bind zona  pellucida is described. The role of zona pellucida glycoproteins in  the binding of sperm, induction of acrosome reactions and avoidance of  polyspermy is discussed. In the second section, the role of various  cytokines, growth factors and immunomodulatory agents in implantation  of embryos is described. In the field of reproductive immunology, one  of the major issues is to explore the successful gestation of the  histoincompatible fetus in the uterus of an immunologically competent  mother. The Proceedings presents the issues of paternal antigens at  the feto-maternal interface and shows that Th2-type of immunity is  involved in normal successful conception. The role of membrane-bound  and soluble HLA-G in protecting the fetus from the lytic activities of  maternal uterine and peripheral blood natural killer (NK) cells is  also presented. \u003cbr\u003e  Nature's experiments suggest that antibodies against sperm-specific  antigens are responsible for infertility in some women. The  possibility that an immunogenetic background contributes to production  of sperm-immobilizing antibodies in infertile women is discussed in  the section on autoantibodies and infertility. The Proceedings  presents the issue of Th1-type cytokines in inducing recurrent  spontaneous abortions of unexplained etiology. The roles of  β2-glycoprotein 1 (β2-GP1)-dependent anticardiolipin  antibody, lupus anticoagulant, antiphospholipids, anti-thyroid  antibody and anti-nuclear antibody in miscarriages are also described.  \u003cbr\u003e  The rising global human population, particularly in the developing  countries, has driven the need for new and safer methods of  contraception. Fertility regulation by vaccines is thus an interesting  proposition. The section on contraceptive vaccines discusses the  latest advances in this area and describes the current status of  vaccines based on βhCG, sperm antigens, zona pellucida  glycoproteins, and riboflavin carrier proteins. \u003cbr\u003e  The issues of mucosal immunity and strategies for enhancing local  genital immune responses to combat HIV infection is discussed. The  role of inflammatory and related cytokines in chorioamnionitis is  described.\u003cbr\u003e  The contents of this Proceedings describes various facets of  reproductive immunology which will help us to design strategies to  combat genital infections and miscarriages caused by immunological  etiology. Descriptions of the molecular basis of gamete recognition,  implantation and survival of the allogenic fetus will help in  designing strategies for overcoming infertility and also new  contraceptive approaches. The Proceedings will be useful to  researchers and clinicians involved in basic or applied research in  the disciplines of reproductive biology, reproductive immunology, and  obstetrics and gynecology. \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-02-29\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792359234\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-4197-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 401\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":46266214809740,"sku":"9780792359234","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792359234.jpg?v=1770815322","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792359234","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}