{"product_id":"9780792340676","title":"Developments in Molecular and Cellular Biochemistry","description":"\u003ch1\u003eDevelopments in Molecular and Cellular Biochemistry\u003c\/h1\u003e \u003ch2\u003eLamers, Jos M.J.; Verdouw, Pieter D.\u003c\/h2\u003e \u003cp\u003eThe chapters in this volume are the Proceedings of the  Satellite Symposium of the XVIth World Congress of the International  Society for Heart Research on `Signal Transduction in Normal and  Diseased Myocardium' which was held in Rotterdam at the Faculty of  Medicine \u0026amp; Health Sciences of the Erasmus University, June 30 and July  1, 1995. \u003cbr\u003e  Diverse and distinct auto-, para-, and endocrine stimuli arriving at  the surface of endothelium, smooth muscle cells, cardiomyocytes and  fibroblasts within the myocardium, engage cell type-specific  receptors, which lead to transmission of signals across the cell  plasma membrane and result in the production and activation of second  messengers. The most common mechanism by which these second messengers  function is via direct or indirect activation of specific protein  kinases. The current challenge for scientists is to identify the  specific substrates (e.g. metabolic enzymes,  Ca\u003csup\u003e2\u003c\/sup\u003e\u003csup\u003e+\u003c\/sup\u003e-regulating proteins, transcription and mitotic  factors) for the many protein kinases, to elucidate the biological  significance of the cell type-specific expression heterogeneity of  signalling proteins (e.g. membrane receptors, isoenzymes of protein  kinase C, G-proteins) and to unravel the cross-talk interaction  between the signalling systems (e.g. phospholipase C with adenylate  cyclase and phospholipase C with phospholipase D). The multiplicity of  receptor types, G-proteins, effector proteins, second messengers and  protein kinases, their substrate proteins and the `cross-talk'  interactions in the myocardium raises fundamental questions about the  mechanisms that ensure the precision and timing of the myocardial  responses to hormonal and pharmacological stimuli. \u003cbr\u003e  This book provides an up-to-date source of information for all  scientists and clinicians interested in the mechanisms by which  external signals are transmitted to the interior and regulation of a  variety of physiological, pathological and pharmacological responses.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1996-06-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792340676\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4613-1275-8\u003c\/p\u003e \u003cp\u003eDimensions: 280cm x210cm\u003c\/p\u003e \u003cp\u003ePages: 274\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":44341172863116,"sku":"9780792340676","price":296.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792340676.jpg?v=1771521506","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792340676","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}