{"product_id":"9780792323808","title":"Immunology and Blood Transfusion: Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe","description":"\u003ch1\u003eImmunology and Blood Transfusion: Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe\u003c\/h1\u003e \u003ch2\u003eSmit Sibinga, C.Th.; Das, P.C.; The, T.H.\u003c\/h2\u003e \u003cp\u003eIn transfusion medicine the scientific fundamentals of  immunology have had a considerable clinical impact. Transfusion may  suppress the immunity but some patients could suffer disadvantages  including GvHD, alloimmunisation and possible cancer, where white  cells (WBC) play pivotal roles in this phenomenon, presenting antigens  and producing cytokines. A clinical application of this practice is  LAK-cells targeted against cancer. MHC on the WBC may provide  additional immunological modulations through series of secondary  messengers. Thus reduction of WBC in the blood and bone marrow may be  advantageous for patients. On the other hand, sharing a part of MHC or  making the transplanted white cells anergic by storage may be even  more advantageous for patients. CMV infection could mimic part of this  MHC.\u003cbr\u003e  UV radiation is effective in the inactivation of the WBC although  filters are easy means for such removal. However, their accurate  quantification requires flow cytometry that has considerable potential  application in blood transfusions. Idiotypic antibody could play an  important role in platelet theory. However, the potential infection  risks in transfusion like HIV and HCV remain, but application of  molecular biological methods like PCR or RT\/PCR has great potentials  in detection of infectious diseases, transplantation and genetic  disorders. Immuno affinity purified concentrates, like factor IX and  protein C, could reduce patients' immune functions, where in the  future protein C could be derived from transgenic animals. Advances  are sure to emerge through adoptive immunotherapy and gene therapies  are exciting prospects when genes transferred into lymphocytes could  be used to correct cell mediated immune deficiency, as in ADA.\u003cbr\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1993-07-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792323808\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-3094-7\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 303.0\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":45378895478924,"sku":"9780792323808","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792323808_70a11036-5b76-460d-b7c7-e57eb3bbeaaf.jpg?v=1765470846","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792323808","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}