{"product_id":"9780792318194","title":"Activators and Inhibitors of Complement","description":"\u003ch1\u003eActivators and Inhibitors of Complement\u003c\/h1\u003e \u003ch2\u003eSim, Robert B.\u003c\/h2\u003e \u003cp\u003eThe complement system is a group of proteins which plays a  major role in the processing and removal of microorganisms and tissue  breakdown products from the circulation and extracellular spaces. The  system is activated by a wide range of targets, and activation leads  to the production of opsonins, chemotaxis of granulocytes, cell lysis  and other biological activities. Inappropriate overactivation of the  system contributes to inflammatory tissue damage in the host, while  inadequate activation leads to accumulation of immune complexes and  other debris in the circulation, and susceptibility to infection. The  biology and biochemistry of the system is now adequately understood,  and attempts can be made to manipulate the activation and activities  of the system for potential therapeutic purposes. \u003cbr\u003e  The reviews in this volume summarise what is known of the ways in  which the complement system can be activated, by interaction with  antibodies, microorganisms, cell debris, and complex carbohydrates and  how the activities and activation of the system have been modified,  accidentally or by design, \u003cem\u003ein vitro\u003c\/em\u003e or \u003cem\u003ein vivo\u003c\/em\u003e by drugs,  venoms, particulate carbohydrates, specific antibodies, synthetic  peptides and other reagents. \u003cbr\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1992-10-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792318194\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-2757-8\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 239.0\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541703454860,"sku":"9780792318194","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792318194.jpg?v=1759292157","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780792318194","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}