{"product_id":"9780751404340","title":"Acyclic, Carbocyclic and L-Nucleosides","description":"\u003ch1\u003eAcyclic, Carbocyclic and L-Nucleosides\u003c\/h1\u003e \u003ch2\u003eAgrofoglio, L.; Challand, S.R.\u003c\/h2\u003e \u003cp\u003eInterest in chemical entities capable of blocking or modifying  cell metabolism ultimately goes back to the discovery of the structure  of DNA in the 1950s. Understanding of the biochemical processes  involved in cell metabolism rapidly led to the idea that compounds  could be designed which might interfere with these processes, and thus  could be used in the treatment of the diseases caused by viral  infection. Since then, several classes of drugs have been discovered  which depend for their effect on modification of the proper  functioning of nucleic acids and, with the introduction of acyclovir  for the treatment of Herpes infections, nucleoside analogues have  become the cornerstone of antiviral chemotherapy. \u003cbr\u003e  The success of the early nucleoside agents, the toxicity and metabolic  instability of many nucleoside analogues, and the effects of viral  pathogens on public health are driving the design, synthesis and  evaluation of new nucleoside analogues, with much attention turning to  nucleosides containing `non natural' sugar analogues. This book  focuses on the development of these agents, and draws together all the  available material in an easily consulted form, which at the same time  guides the reader into the research literature on the subject. Written  primarily for the medicinal chemist, coverage includes both synthetic  strategies and outline guidance on the main trends in biological  activity. Particular attention is drawn to the comparison of synthetic  routes to compounds with their natural analogues. Finally, the  important antiviral activities of the compounds are treated, including  anti-retrovirus, anti-hepadnavirus and anti-herpes virus properties.  \u003cbr\u003e  Written mainly for medicinal chemists in the pharmaceutical industry  and synthetic organic chemists in academe, this book will also be  attractive to researchers in institutions focusing on cellular  metabolism. Advanced students of organic chemistry will find the clear  discussion of the synthetic strategies adopted in the development of  these compounds a useful introduction to this exciting and challenging  area.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1998-10-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780751404340\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-007-0816-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 383\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":46312381284492,"sku":"9780751404340","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780751404340.jpg?v=1771525052","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780751404340","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}