{"product_id":"9780470978320","title":"Chitosan-Based Systems for Biopharmaceuticals Delivery, Targeting and Polymer Therapeutics","description":"\u003ch1\u003eChitosan-Based Systems for Biopharmaceuticals\u003c\/h1\u003e\u003ch2\u003eDelivery, Targeting and Polymer Therapeutics\u003c\/h2\u003e\u003ch3\u003eBruno Sarmento | Jose das Neves\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Organic\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eChitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs.  \u003cp\u003e\u003ci\u003eChitosan-Based Systems for Biopharmaceuticals\u003c\/i\u003e provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential.\u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003echemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals\u003c\/li\u003e \u003cli\u003ephysical properties of chitosan and derivatives in sol and gel states\u003c\/li\u003e \u003cli\u003eabsorption promotion properties of chitosan and derivatives\u003c\/li\u003e \u003cli\u003ebiocompatibility and biodegradation of chitosan and derivatives\u003c\/li\u003e \u003cli\u003ebiological and pharmacological activity of chitosan and derivatives\u003c\/li\u003e \u003cli\u003ebiological, chemical and physical compatibility of chitosan and biopharmaceuticals\u003c\/li\u003e \u003cli\u003eapproaches for functional modification or crosslinking of chitosan\u003c\/li\u003e \u003cli\u003euse of chitosan and derivatives in conventional biopharmaceutical dosage forms\u003c\/li\u003e \u003cli\u003emanufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals\u003c\/li\u003e \u003cli\u003echitosan and derivatives for biopharmaceutical use: mucoadhesive properties\u003c\/li\u003e \u003cli\u003echitosan-based systems for mucosal delivery of biopharmaceuticals\u003c\/li\u003e \u003cli\u003echitosan-based delivery systems for mucosal vaccination\u003c\/li\u003e \u003cli\u003echitosan-based nanoparticulates for oral delivery of biopharmaceuticals\u003c\/li\u003e \u003cli\u003echitosan-based systems for ocular delivery of biopharmaceuticals\u003c\/li\u003e \u003cli\u003echemical modification of chitosan for delivery of DNA and siRNA\u003c\/li\u003e \u003cli\u003etarget-specific chitosan-based nanoparticle systems for nucleic acid delivery\u003c\/li\u003e \u003cli\u003efunctional PEGylated chitosan systems for biopharmaceuticals\u003c\/li\u003e \u003cli\u003estimuli-sensitive chitosan-based systems for biopharmaceuticals\u003c\/li\u003e \u003cli\u003echitosan copolymers for biopharmaceuticals\u003c\/li\u003e \u003cli\u003eapplication of chitosan for anti-cancer biopharmaceutical delivery\u003c\/li\u003e \u003cli\u003echitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine\u003c\/li\u003e \u003cli\u003ewound healing properties of chitosan and its use in wound dressing biopharmaceuticals\u003c\/li\u003e \u003cli\u003etoxicological properties of chitosan and derivatives for biopharmaceutical applications\u003c\/li\u003e \u003cli\u003eregulatory status of chitosan and derivatives\u003c\/li\u003e \u003cli\u003epatentability and intellectual property issues\u003c\/li\u003e \u003cli\u003equality control and good manufacturing practice\u003c\/li\u003e \u003cli\u003epreclinical and clinical use of chitosan and derivatives for biopharmaceuticals\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eChitosan-Based Systems for Biopharmaceuticals\u003c\/i\u003e is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eBruno Sarmento,\u003c\/b\u003e Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal \u0026amp; CICS, Department of Pharmaceutical Sciences, Instituto Superior de Ciências da Saúde–Norte, Gandra, Portugal  \u003cp\u003e\u003cb\u003eJosé das Neves,\u003c\/b\u003e Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e12 March 2012\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470978320\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e584\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e39.52\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379962638476,"sku":"9780470978320","price":192.56,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470978320.jpg?v=1780239035","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470978320","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}