{"product_id":"9780470772744","title":"Cardiotoxicity of Non-Cardiovascular Drugs","description":"\u003ch1\u003eCardiotoxicity of Non-Cardiovascular Drugs\u003c\/h1\u003e\u003ch2\u003e\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eContributors:\u003c\/strong\u003e Minotti, Giorgio\u003c\/p\u003e\u003cp\u003eSome drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use.  \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eCardiotoxicity of Non-Cardiovascular Drugs\u003c\/i\u003e international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e metabolic targets of cardiotoxicity\u003c\/li\u003e \u003cli\u003eregulatory aspects\u003c\/li\u003e \u003cli\u003etranslating molecular mechanisms into clinical trials\u003c\/li\u003e \u003cli\u003estructure-activity relationships in arrhythmias by antihistamines and psychoactive drugs\u003c\/li\u003e \u003cli\u003ecardiovascular toxicity of antitumor drugs\u003c\/li\u003e \u003cli\u003ecardiovascular toxicities of non-steroidal anti-inflammatory drugs\u003c\/li\u003e \u003cli\u003ecardiovascular toxicities of antiretroviral therapies\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eCardiotoxicity of Non-Cardiovascular Drugs\u003c\/i\u003e is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.\u003c\/p\u003e\u003ch3\u003eBook Details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Wiley\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e 2010-05-24\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Hardcover\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9780470772744\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 360\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44314360447116,"sku":"9780470772744","price":148.45,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470772744_5fdc8143-1411-4ccc-8bc2-5281b32ade8e.jpg?v=1768916658","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470772744","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}