{"product_id":"9780470723333","title":"The Biology of Extracellular Molecular Chaperones","description":"\u003ch3\u003eNovartis Foundation Symposia\u003c\/h3\u003e\u003ch1\u003eThe Biology of Extracellular Molecular Chaperones\u003c\/h1\u003e\u003ch3\u003eDerek J. Chadwick | Jamie A. Goode\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Cell Biology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eThe heat shock, or cell stress, response was first identified in the polytene chromosomes of \u003ci\u003eDrosophila\u003c\/i\u003e. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.  \u003cp\u003eSince the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.\u003c\/p\u003e \u003cp\u003eMore recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.\u003c\/p\u003e \u003cp\u003eThis is the first book bringing leading researchers in this field together to review and discuss:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eour current knowledge of cell stress response and molecular chaperones\u003c\/li\u003e \u003cli\u003ethe changing paradigms of protein trafficking and function\u003c\/li\u003e \u003cli\u003ecell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules\u003c\/li\u003e \u003cli\u003ethe role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Biology of Extracellular Molecular Chaperones\u003c\/i\u003e is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cstrong\u003eThe Novartis Foundation\u003c\/strong\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChair:\u003c\/strong\u003e Péter Csermely. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e05 May 2008\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470723333\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e248\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e19.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44314209910924,"sku":"9780470723333","price":197.96,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470723333_82d8c314-8bca-44e6-9038-68bf38e01cc8.jpg?v=1780179067","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470723333","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}