By providing expositions to modeling principles, theories, computational solutions, and open problems, this reference presents a full scope on relevant biological phenomena, modeling frameworks, technical challenges, and algorithms.

• Up-to-date developments of structures of biomolecules, systems biology, advanced models, and algorithms
• Sampling techniques for estimating evolutionary rates and generating molecular structures
• Accurate computation of probability landscape of stochastic networks, solving discrete chemical master equations
• End-of-chapter exercises

BHASKAR DASGUPTA is a Professor in the Computer Science department at the University of Illinois at Chicago, USA. He has written numerous bioinformatics research papers. Dr. DasGupta was the recipient of the NSF CAREER award in 2004 and the UIC College of Engineering Faculty Teaching award in 2012.

JIE LIANG is the Richard and Loan Hill Professor within the Department of Bioengineering and Department of Computer Science at the University of Illinois at Chicago, USA. He earned his Ph.D. in Biophysics. He was an NSF CISE postdoctoral research associate (1994-1996) at the Beckman Institute and National Center for Supercomputing and its Applications (NCSA), as well as a visiting fellow at the NSF Institute of Mathematics and Applications at Minneapolis. He was a recipient of the NSF CAREER award in 2003. He was elected a fellow of the American Institute of Medicine and Biological Engineering in 2007. He was a University Scholar (2010-2012).