{"product_id":"9780470281741","title":"Enzyme Inhibition in Drug Discovery and Development The Good and the Bad","description":"\u003ch1\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/h1\u003e\u003ch2\u003eThe Good and the Bad\u003c\/h2\u003e\u003ch3\u003eChuang Lu | Albert P. Li\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eThe science and applied approaches of enzyme inhibition in drug discovery and development  \u003cp\u003eOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.\u003c\/p\u003e \u003cp\u003eWith chapters written by over fifty leading experts in their fields, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the \"good\" inhibitions—desirable pharmacological effects—and \"bad\" inhibitions—drug–drug interactions and toxicity. The book discusses:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eThe drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eChuang Lu, PhD\u003c\/b\u003e, is the Associate Director in the Drug Safety and Disposition Department of Millennium Pharmaceuticals. His current research interests include drug-metabolizing enzymes, drug–drug interaction, and in vitro–in vivo correlation.  \u003cp\u003e\u003cb\u003eAlbert P. Li, PhD\u003c\/b\u003e, is the President and CEO of In Vitro ADMET Laboratories, LLC and Advanced Pharmaceutical Sciences, Inc., and the cofounder, Chairman, and CSO of the ADMET Group. His experience spans over twenty-five years in the drug development industry, with over 150 publications. He is the editor of several books, including \u003ci\u003eDrug–Drug Interactions in Pharmaceutical Development\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e07 January 2010\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470281741\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e876\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e46.24\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310508077196,"sku":"9780470281741","price":233.96,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470281741.jpg?v=1780283472","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470281741","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}