{"product_id":"9780470058138","title":"Fragment-Based Drug Discovery A Practical Approach","description":"\u003ch1\u003eFragment-Based Drug Discovery\u003c\/h1\u003e\u003ch2\u003eA Practical Approach\u003c\/h2\u003e\u003ch3\u003eEdward R. Zartler | Michael Shapiro\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Industrial \u0026amp; Technical\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery.  \u003cp\u003e\u003ci\u003eFragment-Based Drug Discovery: A Practical Approach\u003c\/i\u003e is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003ean introduction to  fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort.\u003c\/li\u003e \u003cli\u003esetting up an FBDD project\u003c\/li\u003e \u003cli\u003elibrary building and production\u003c\/li\u003e \u003cli\u003eNMR in fragment screening and follow up\u003c\/li\u003e \u003c\/ul\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eapplication of protein-ligand NOE matching to the rapid evaluation of fragment binding poses\u003c\/li\u003e \u003cli\u003etarget immobilized NMR screening: validation and extension to membrane proteins\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003ein situ\u003c\/i\u003e fragment-based medicinal chemistry: screening by mass spectrometry\u003c\/li\u003e \u003cli\u003ecomputational approaches to fragment and substructure discovery and evaluation\u003c\/li\u003e \u003cli\u003evirtual fragment scanning:  current trends, applications and web based tools\u003c\/li\u003e \u003cli\u003efragment-based lead discovery using covalent capture methods\u003c\/li\u003e \u003cli\u003ecase study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWith contributions from industry experts who have successfully set up an industrial fragment-based research program, \u003ci\u003eFragment-Based Drug Discovery: A Practical Approach\u003c\/i\u003e offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eEdward R. Zartler\u003c\/b\u003e, Strategy Consultant, Eli Lilly \u0026amp; Co.; Established the Fragment-based Drug Design paradigm at Eli Lilly.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMichael J. Shapiro\u003c\/b\u003e, Associate Professor of Pharmacy, University of Maryland School of Pharmaceutical Sciences; Industry experience at Lilley, Novartis and Sandoz.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e15 December 2008\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470058138\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e296\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e25.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44380393832588,"sku":"9780470058138","price":213.26,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470058138_ea244d26-f159-4e3a-9505-9b1e42da303d.jpg?v=1780172704","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470058138","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}