{"product_id":"9780470057667","title":"Novartis Foundation Symposia: Bridging the Trans-Disciplinary Divide","description":"\u003ch1\u003eNovartis Foundation Symposia\u003c\/h1\u003e\u003ch2\u003eBridging the Trans-Disciplinary Divide\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eContributors:\u003c\/strong\u003e Chadwick, Derek J.; Goode, Jamie A.\u003c\/p\u003e\u003cp\u003ePart of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eAcetaldehyde-Related Pathology\u003c\/i\u003e\u003c\/b\u003e describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. \u003cb\u003e\u003ci\u003eAcetaldehyde-Related Pathology\u003c\/i\u003e\u003c\/b\u003e features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology.\u003c\/p\u003e \u003cp\u003eThis book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.\u003c\/p\u003e\u003ch3\u003eBook Details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Wiley\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e 2007-06-05\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Hardcover\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9780470057667\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 286\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310798401676,"sku":"9780470057667","price":228.56,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470057667_77248eea-d500-4fc5-a3dc-72bbc28c2bcb.jpg?v=1768916774","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780470057667","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}