{"product_id":"9780306458958","title":"Enzyme-Prodrug Strategies for Cancer Therapy","description":"\u003ch1\u003eEnzyme-Prodrug Strategies for Cancer Therapy\u003c\/h1\u003e \u003ch2\u003eMelton, Roger G.; Knox, Richard J.\u003c\/h2\u003e \u003cp\u003eAntibody-directed enzyme prodrug therapy (ADEPT) directly  addresses the major problem in cancer chemotherapy-its lack of  selectivity. Antibody delivery combined with the amplification  provided by the enzymatic activation of prodrugs enables selection to  be made between tumour and normal tissue. ADEPT offers a novel field  of opportunities in the therapy of systemic cancer and may be a major  advance for the treatment of solid tumours.\u003cbr\u003e  This book is the first to describe ADEPT in detail. Each chapter  reviews an aspect of the immunology, enzymology, biochemistry,  chemistry, and cancer chemotherapy which have been integrated into the  ADEPT concept. An additional chapter describes the related approach of  gene-directed enzyme prodrug therapy (GDEPT). This latter approach is  still in its infancy but ADEPT has entered the clinic. The initial  clinical studies with ADEPT are included and discussed in detail.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1999-01-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780306458958\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4823-2\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 257\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46265709723788,"sku":"9780306458958","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780306458958.jpg?v=1770788700","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9780306458958","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}